Looking for something?

Find it in our extensive resource library!

Smart Filters

  • Reset
  • Services

  • Who it's for

  • What it’s about

  • Format

View: 76

Download: 0

Skin biopsy

What is a skin biopsy?

A skin biopsy is a short procedure used to take a small piece of skin. This is then sent to the laboratory. Here, they can look at it under a microscope, or grow more cells from it.

Why does my child need a skin biopsy?

We take a skin biopsy to help us confirm or rule out a diagnosis. The reason for this skin biopsy will be explained to you by your doctor.

Written consent

Before your child has their skin biopsy, the doctor will give you a full explanation of what it will involve. You will then have the chance to ask any questions that you might have. You will then be asked to sign a written consent form. This gives your doctor permission to do the biopsy.

How is the skin biopsy taken?

A skin biopsy is usually taken while your child is awake, but sometimes they will be given a medicine to help them feel relaxed and sleepy. This is known as sedation.

A cream is rubbed onto the area of skin where the biopsy is going to be taken. This will make the skin numb, so that it does not hurt when the skin is taken. After about 45 minutes, the cream is wiped away. Your child might need a little bit of anaesthetic injected in the skin to make it fully numb.

When the skin is numb, a small circle of skin is removed. This circle is 3mm wide or less, and is taken using a tool called a punch biopsy. This is gently inserted into your child’s skin, carefully turned, and a small circle of skin is taken.

When the skin has been taken, the small wound will be closed. This is done using either a couple of steri-strips, which are thin strips of plaster, or with a couple of stitches.

After the skin biopsy


If the wound has been closed with steri-strips, the advice is to:

  • keep them dry
  • leave them in place for 10 days
  • after 10 days, soak them in warm water and gently peel them off


If the wound has been closed with stitches, you are advised to:

  • keep them dry for 2 days
  • arrange an appointment with your specialist nurse or GP practice to have the stitches removed


After the skin biopsy has been sent to the laboratory, it can take a few weeks before they have results of the tests. An appointment will be made in clinic to give you these results.


Every procedure that cuts into the skin has a risk of minor complications. This is also true for skin biopsies.


There is a small risk of bleeding during the biopsy, and straight after the procedure. This is usually very minor, and is stopped by pressing onto the area with gauze.


There will likely be some soreness around the place where the skin was taken. This will not last for very long, and some paracetamol (or Calpol) should help with the pain. Use this as the directions on the bottle or packet say.


There is a small risk of infection after a skin biopsy. If the biopsy site does become infected, a short course of antibiotics might be needed. You can spot an infection by looking out for redness, pain, swelling, and oozing (liquid, pus, or goo) coming out of the wound.

If you are worried about an infection, be sure to get in touch with your doctor or GP as soon as you can.

Is something missing from this resource that you think should be included? Please let us know

Contact us


Please note this is a generic information sheet relating to care at Sheffield Children’s. The details in this resource may not necessarily reflect treatment at other hospitals. This information is not intended as a substitute for professional medical care. Always follow your healthcare professionals’ instructions. If this resource relates to medicines, please read it alongside the medicine manufacturer’s patient information leaflet. If you have specific questions about how this resource relates to your child, please ask your doctor.

How useful did you find this resource?*

Metabolic Medicine Nursing Team

Email: scn-tr.sheffieldmetabolicnurses@nhs.net


0114 3053798 (direct) or 0114 271 7000 and ask them to page bleep 236



Western Bank
S10 2TH

United Kingdom

Switchboard: 0114 271 7000

Interesting Facts

We’ve got a special MRI scanner just for teddies so children can see what it’s like before they have a scan.

Help to transform our extraordinary hospital into something even better.

Sheffield Children's@SheffChildrens
Harriet Keynes, our Corporate Partnerships Assistant, added: “Thank you so much to Dave, Cycling Sheffield, Burro… https://t.co/oei1NV2a0z

As of 6 July 2022 everyone (colleagues, patients and families) must wear a mask. This applies to all spaces across. all sitesMore information on how we are keeping you safe is available here.

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.