Nebulised DNase (Pulmozyme) in cystic fibrosis

Nebulisers are used to convert liquid medicines into fine droplets which can be breathed directly into the lungs. Your child has been prescribed DNase (Pulmozyme).

DNase is a copy of an enzyme that occurs naturally in the body. It helps to thin down sticky mucus and makes it easier to clear.

When should it be taken?

DNase should be taken 1 time a day every day. It will be discussed with you when it is best to fit DNase into your routine. It is however recommended that you do not take your DNase immediately before you do your physio as it will not work effectively.

How should it be stored?

DNase must be stored in the fridge.

Instructions for taking DNase

You will be given a nebuliser unit and shown how to use this and how to clean it.

It is important that you wash your hands before setting up the nebuliser.

The nebuliser must be cleaned after each use and you will be shown how to do this.

The nebuliser must be serviced every year so please make sure you contact the team if you notice your nebuliser is due for service. It is important that you use the correct nebuliser pot or chamber for your DNase as if it mixes with other medications it may not work as effectively.

Side effects

When starting DNase the dose will be given at the hospital so that we can check there are no problems. Please read the information leaflet provided with the DNase and if there are any adverse affects stop taking the medication and contact the hospital.

Your treatment plan for DNase

The type of nebuliser you have been given is:  

Specific instructions for your nebuliser are: