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Nebulised DNase (Pulmozyme) in cystic fibrosis

Nebulisers are used to convert liquid medicines into fine droplets which can be breathed directly into the lungs. Your child has been prescribed DNase (Pulmozyme).

DNase is a copy of an enzyme that occurs naturally in the body. It helps to thin down sticky mucus and makes it easier to clear.

When should it be taken?

DNase should be taken 1 time a day every day. It will be discussed with you when it is best to fit DNase into your routine. It is however recommended that you do not take your DNase immediately before you do your physio as it will not work effectively.

How should it be stored?

DNase must be stored in the fridge.

Instructions for taking DNase

You will be given a nebuliser unit and shown how to use this and how to clean it.

It is important that you wash your hands before setting up the nebuliser.

The nebuliser must be cleaned after each use and you will be shown how to do this.

The nebuliser must be serviced every year so please make sure you contact the team if you notice your nebuliser is due for service. It is important that you use the correct nebuliser pot or chamber for your DNase as if it mixes with other medications it may not work as effectively.

Side effects

When starting DNase the dose will be given at the hospital so that we can check there are no problems. Please read the information leaflet provided with the DNase and if there are any adverse affects stop taking the medication and contact the hospital.

Your treatment plan for DNase


The type of nebuliser you have been given is:  

Specific instructions for your nebuliser are:  

Contact us

If you have any questions of concerns please call 0114 271 7273 or 0114 271 7375.

You must always discuss the individual treatment of your child with the appropriate member of staff. Do not rely on this resource alone for information about your child’s treatment.

Is something missing from this resource that you think should be included? Please let us know

Contact us


Please note: this is a generic information sheet relating to care at Sheffield Children’s NHS FT. These details may not reflect treatment at other hospitals. This information is not intended as a substitute for professional medical care. Always follow your healthcare professionals’ instructions. If this resource relates to medicines, please read it alongside the medicine manufacturer’s patient information leaflet. If this information has been translated into another language from English, efforts have been made to maintain accuracy, but there may still be some translation errors. If you are unsure about any of the guidance in this resource or have specific questions about how it relates to your child, always ask your healthcare professional for further advice.

Resource number: CF16

Resource Type: Article

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