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Luteinising hormone releasing hormone (LHRH) stimulation test

What is a LHRH test?

A luteinising hormone-releasing hormone (LHRH) test sees how well the pituitary gland (a tiny bit inside the brain) regulates the level of sex hormones in the body. It also helps regulate the amount of hormones produced by other glands in the body.

How does the test work?

In this test, we will stimulate the pituitary gland to produce hormones that cause puberty. These are luteinising hormone (LH) and follicle stimulating hormone (FSH).

We will then take a few blood tests to check these hormone levels in your blood.

The easiest way to do this is with a cannula in the vein in the back of your hand or arm. We will give you a local anaesthetic cream or cold spray to help with any pain or discomfort.

Once the cannula is in, you can play with toys, read books and watch TV.

The test will take around 2 hours.

Can I eat or drink before the test?

You can bring your favourite snack and drink, or you may be given toast, juice, cereal or a snack.


Prescribed medications should be taken as normal prior to admission unless otherwise advised. Please bring with you all medications that your child is taking.

What happens after my test?

You will not be discharged until you have recovered from the test.

It is best if you can arrange your own transport home in a car rather than public transport as you can be very tired after the test.

You should be able to return to your normal activities the following day.

Specific care instructions will be given prior to discharge by the nurse performing the test.

When will I get my results?

The results of the test will take about a month to be analysed. Your consultant may write to you with the results or discuss them at your next appointment.

Contact us

If you have any questions or concerns, please contact the endocrine clinical nurse specialists on: 0114 226 7815 between 8.30am and 5pm.
Out of these hours please contact the on-call medical team at Sheffield Children’s hospital on: 0114 271 7000

Further resources

Please read our resource for more information about risks of anaesthetics.

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Please note: this is a generic information sheet relating to care at Sheffield Children’s NHS FT. These details may not reflect treatment at other hospitals. This information is not intended as a substitute for professional medical care. Always follow your healthcare professionals’ instructions. If this resource relates to medicines, please read it alongside the medicine manufacturer’s patient information leaflet. If this information has been translated into another language from English, efforts have been made to maintain accuracy, but there may still be some translation errors. If you are unsure about any of the guidance in this resource or have specific questions about how it relates to your child, always ask your healthcare professional for further advice.

Resource number: END18

Resource Type: Article

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